Megan Jovon Ruth Pete was born on February 15, 1995, in San Antonio, Texas, and her mother, Holly Thomas, immediately moved to Houston.

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When Megan showed Thomas her rapping skills at age 18, Thomas required that she wait until she was 21 to pursue rapping as a career.

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Pete studied at Texas Southern University and graduated on December 11, 2021, with a Bachelor of Science in health administration.

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In April 2016, Megan Thee Stallion released her first single "Like a Stallion" followed by the exclusive mixtapes Rich Ratchet, and Megan Mix (2017).

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In 2017, Megan Thee Stallion released the song Stalli (Freestyle), as a rework of late musician XXX Tentacion's "Look at Me!".

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In early 2018, Megan Thee Stallion signed with 1501 Certified Entertainment, run by T. Farris and owned by former baseball player Carl Crawford.

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On January 22, 2019, Megan Thee Stallion released "Big Ole Freak" as a single from her EP, Tina Snow, and also filmed a music video for the track.

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In January 2020, Megan Thee Stallion released the single "Diamonds" with singer Normani, for the soundtrack of the superhero film Birds of Prey released the same year.

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On February 15, 2022 - her birthday - Megan Thee Stallion announced the launching of a nonprofit, the Pete and Thomas Foundation.

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On August 11, 2022, Megan Thee Stallion took to Twitter to announce release of her second studio album Traumazine.